What I want to do most in Cyberpunk 2077 is see how extreme you can modify your character's body with cybernetic implants, and see how far you can blur the line between man and machine.
I believe at some point in the future, the majority of people in the real world will have cybernetic enhancements. Whether it's something minor like magnetic implants in the fingertips or something major like an eye implant that drastically increases the strength and precision of someone's vision, both are which already exist today, at some point 100% natural, implant free humans will be in the minority.