The lead writer of Baldur's Gate 3's Dark Urge was extremely squeamish at first, which shows you can do just about anything if you set your mind to it
"It desensitised me to everything."
www.pcgamer.com
As a squeamish person myself, I must say they did a great job. I expected a more murder-hobo feeling, but "the contrast between euphemistic writing and bloody mayhem", as the article says, makes it much more unsettling. I intended to do a fully evil playthrough, but I'm not sure if I'll actually be able to. Luckily you aren't forced to while playing The Dark Urge, so I'll probably try to redeem myself, at least as much as possible.