Playing through the Ezio trilogy is still my favorite video game experience to this day. Assassin's Creed I was the first single-player game I had played so when the next in the series was announced, promoting twice the number of hidden blades, I was incredibly excited. Ezio had equal parts charm, tragedy, and wisdom. A beguiling rogue whose life path was never his own. What always hooked me into these games was the relationship between those in the present and the past. At the end of ACII Minerva calls out to Desmond in the future, looking past Ezio. Then, at the end of Ezio's (playable) story, Ezio encounters Desmond again and speaks to him. Ezio recognizes, and finally accepts, he is merely a courier for some greater power beyond his understanding. In a way, Ezio's greatest achievements were never his own, Desmond wasn't a passive onlooker into the past gleaning information, his existence in the future formed Ezio's entire life once he encountered Minerva. I absolutely love Ezio's somewhat sad story.
In recent years, after Ubisoft's reimaging of the game series, I've enjoyed Odyssey a lot. The story elements are somewhat similar. Kassandra is a conduit for Layla, but with the wider RPG elements, and the fantastical, very present, mythos, any humanizing central themes/story gets a little muddled with miscellaneous side quests and minotaurs. It's almost unrecognizable to the early games, but it's still fun being a historical character and interacting with an ancient world.