I am really excited to play the game twice, it sounds like branching story paths and character choice are such deep seated mechanics in the world. First time through I think I will play a decker/hacker type, lots of points in Cool, sarcastic/wise ass conversation choices when available, but if the going gets tough the character will buckle and make the selfish choice. Neutral Evil I suppose.
The 2nd play through will be me trying to min/max the game. Higher difficulty if that's a thing, full combat, mix of firearms and melee, classic street-samurai bruiser with a heart of gold. But if a choice is like "this side character you don't care about lives and you get a pittance VS you get one of the best upgrades in the game and they die" then I will definitely be letting them get geeked. Think Conan the Barbarian but driven by body augmentation.