Based on the trailers and gameplay demos, there seem to be so many things to do in the game (I mean, there are going to be really specific character customisation options with Genital Jousting possibly helping out) but if I had to choose one it would be climbing to the top of the highest building at night, take in the view and relax (if possible have a drink), then perform a leap of faith to the bottom and try to maximize time of flight.