This isn't a "best of" list per se, as it's way too subjective depending upon what game genres you play as well as your preference in gameplay. RPGs, shooters, strategy, and immersive sims games can challenge the player with quests, questlines, missions, and campaigns that need to be completed. A single or series of challenges, obstacles, decisions that the player must make to continue, be it a non-combat or combat scenario. Some of these stick in our minds years after we've played the games, for whatever reason, and not necessarily on any established "best of" list.
Just off the top of my head, these are the quests that come to mind first when I think about the following games:
The Witcher 3, Bloody Baron Questline - It's technically more of The Search for Ciri (in Velen), as it's numerous quests all linked together, but to me, it all revolves around the Bloody Baron himself.
Baldur's Gate 1, Minsc's quest to save Dynaheir - There are a lot of excellent quests in both BG 1 & BG 2, but the one that always comes to mind first is this quest. Low level party traveling across multiple unknown maps and assaulting/surviving the assault on the Gnoll stronghold.
Dragon Age Origins, The Battle of Denerim - I don't normally like final battles, but this one is long, covers several maps, and makes you ultilize every skill you and your party know. It's also got this cool scene where all the party members you don't take with you have a brief "goodbye" conversation.
Mass Effect 2, Shadow Broker's Lair (DLC) - There are a lot of excellent quests in both ME2 and ME3, but the one I always remember from ME2 is Lair of the Shadow Broker, as it brings back Liara and sends you on a long multi-location quest, culminating in what I though was the toughest battle in the game. Plus you get to romance Liara if she's your LI.
Skyrim, The Blessings of Nature - Skyrim, like most of Bethesda's games of a lot of non-memorable or repetitive quests, but this one has always stood out as unique when I think of Skyrim. It can be a long quest, depending upon how many times you get sidetracked with other quests on the way to Eldergleam Sanctuary, but I find that there's a real sense of satisfaction in replacing a dying tree with a sapling and watching grow throughout the game.
Just off the top of my head, these are the quests that come to mind first when I think about the following games:
The Witcher 3, Bloody Baron Questline - It's technically more of The Search for Ciri (in Velen), as it's numerous quests all linked together, but to me, it all revolves around the Bloody Baron himself.
Baldur's Gate 1, Minsc's quest to save Dynaheir - There are a lot of excellent quests in both BG 1 & BG 2, but the one that always comes to mind first is this quest. Low level party traveling across multiple unknown maps and assaulting/surviving the assault on the Gnoll stronghold.
Dragon Age Origins, The Battle of Denerim - I don't normally like final battles, but this one is long, covers several maps, and makes you ultilize every skill you and your party know. It's also got this cool scene where all the party members you don't take with you have a brief "goodbye" conversation.
Mass Effect 2, Shadow Broker's Lair (DLC) - There are a lot of excellent quests in both ME2 and ME3, but the one I always remember from ME2 is Lair of the Shadow Broker, as it brings back Liara and sends you on a long multi-location quest, culminating in what I though was the toughest battle in the game. Plus you get to romance Liara if she's your LI.
Skyrim, The Blessings of Nature - Skyrim, like most of Bethesda's games of a lot of non-memorable or repetitive quests, but this one has always stood out as unique when I think of Skyrim. It can be a long quest, depending upon how many times you get sidetracked with other quests on the way to Eldergleam Sanctuary, but I find that there's a real sense of satisfaction in replacing a dying tree with a sapling and watching grow throughout the game.