What I'd like to do is make a stealth-hacking build and just explore the world, do all the side quests, hack everything and turn it against my opponents or watch them from the shadows and manipulate them in various ways.
Do and see as much as possible in one playthrough and then start with a new character, this time focused on the social aspects and on diplomatic resolutions in quests and see what changes.
Lastly, do another playthrough where I make a combat oriented character and basically, well, kill everyone. And see what changes.
After I'm done with these 3 experiments I'm going to use the meta knowledge I acquired to mix and match elements from these playstyles to find a fun combination. Also, going to try to min-max as much as possible to make an ultimate build that can do everything, if possible.
And this is just the beginning....