If you arent organizing your Jokers into order what the hell are you doing ?
Flush is good very early on but rarely ends up being the best hand to focus on.
From what I remember, on the higher difficulties you dont get any money for the first blind so especially early when theres no money to buy anything if theres any useful bonus there at all I just skip.
I usually try and keep money in the bank to keep interest rolling in, unless theres something really strong that justifies spending the money.
I rarely choose to augment cards until I know what hand is going to be my go-to for the game. The chance of pulling them is small and the bonus for doing it is rarely very big anyway.
Early on Im looking for any + multi or extra chips joker at all, preferably both, getting ahead of the curve lets you focus on getting money to cycle the shop for better late game jokers.
Later on an X multi and then anything that scales over time need to be added, like the ones that add multi for using planet/tarot cards or whatever else.
I dont like jokers that focus on a suit because the game will always pull the old 'X suit doesnt score' on a boss blind if I do.
I never pick up a Joker in the hope I'll be able to use it later. The ones that give bonuses for having Steel cards if you dont have any yet for example.