In Dnd, aka BG1, BG2 and Icewindale.
Probably: Web or entangle, followed by a couple of Fireballs or Cloudkill!! (even works on golems kinda.)
Somtimes, already knowing where they are located...
(Its kinda cheating in a way, but somtimes the odds are unfair anyway.)
Gets a fight in my favor often :0)