I don't get what you mean by hot keys? Do you just mean the RTS convention of selecting a bunch of units then assigning them all to a single key press? Sacrifice and the newer (meaning not-1980's) BattleTech games both did that, but those were essentially 3D RTS games.
Try playing StarCraft II - you will use hotkeys for everything, including micro and macro. Without them you will play like a turtle. A very sleepy turtle. With hotkeys memorized your hand will fly through keyboard like a madman and genius pianist.