With a big dose of help from EA, Cities Skylines sort of trounced SimCity into oblivion. Now Paradox is coming out in September with a life sim that could do the same for abused fans (see DLCs) of The Sims. So far as I can tell, this will be the first mainstream game to use AI to create "real" conversations and reactions from NPCs. Pardon my enthusiasm, but this will make large swaths of the world's games seem like they are from an older, possibly even outdated, generation.
PC Gamer has a couple of articles up about the new game, though they don't mention the AI; one, two
PC Gamer has a couple of articles up about the new game, though they don't mention the AI; one, two