I wonder if they will have a female protagonist? Rumors have it the game will be set in Florida, and I'm hoping for more than just Vice City. It would be interesting to actually use the airports in the game, but I think that's gonna be a high bar to cross.
/looks at board with yarn strung between push pins
Exhibit A
The host of Vinewood Boulevard Radio is named Sam Flax (in game). Sam Flax is a real person who founded Art Supply Stores across the east coast. Orlando is home to one of those stores.
https://www.samflaxorlando.com/about
Exhibit B
The "Pride Not Prejudice 1" radio commercial
"Some games are set in hell, others in post-apocalyptic wastelands. Now, there's a shooter set in the most culturally terrifying place in the world. The South." It is contended whether Florida is part of "The South" or actually it's own region of North America
https://images.app.goo.gl/zmnXGzWBgB4bVgou6
Exhibit C
Since it's inception in the original GTA, the game revealed locations in the following order: Liberty City, Vice City, then San Andreas. GTAV broke that format. Unless Rockstar chooses a totally new location, there is a good chance things will be centered around Vice City.
I'm hoping that we really get more than just the Vice City area. I'm talking a good half of Florida, up to, yes, Orlando and it's theme parks. Seeing as how you can drive from Orlando to Miami in a good 4-5 hours (at GTA speed it would probably be more like 2), it's not unreasonable that they would connect the cities by highway, and I'm figuring in game this would probably be about a 20-30 minute drive. Or, perhaps, you can just book a flight and take a rental car. I want to see the Keys, the Everglades, Palm Beach and Lake Okeechobee, too. And I'll have two number sevens with extra dip.