Repetitive Looting
I love the Far Crys from 3 on, but I hate one thing they all have in common: individual looting complete with animation.
I could easily end up with a dozen bad guys lying around after a skirmish, and it's a major pain to have to go thru 12 looting actions. There needs to be an Area of Effect on looting—by all means make it a skill which has to be acquired, or money which has to be paid… but stop this repetitive stupid grind!
Ending drags
I also love the Civilization games, but again one thing in common: the game becomes less interesting the further it goes along, to the point where late game is a real drag/slog. I had a recent couple of months on Civ4—I think I finished 2 games, abandoned all other dozens somewhere between Education and Scientific Method.
Big Change at Halfway
Another peeve which affects 2 games I love & replay every year: Crysis and Crysis Warhead. The dev Crytek did the same in both those that they did with the original Far Cry— introducing a major change in genre/playstyle halfway thru.
In Far Cry 1, it was the intro of the Trigen mutants, nowhere near as interesting as the mercs in the first half. In both Crysis games, it was the intro of the Aliens into what up to then was a standard fun soldier combat game. Devs, don't turn a checkers game into chess halfway thru! Do what Ubisoft do with Far Cry franchise—make the different stuff either an expansion/spin-off, or a DLC.
No 1-click Resume
Applies to every game I love. In 90+% of occasions I launch a game, I want to continue where I left off. Why do devs not allow this? I don't care if it takes longer to launch my way, I can do something useful and come back to my ready-to-play game.
No 1-click Exit
Same deal at other end—a button which creates the save-game 1-click Resume will use, and gracefully exits to desktop.
Maybe the last 2 are too general for this thread, but it annoys me with every game.