What programs are you using? As a gaming forum its possible you would be better off asking at a more hardware orientated forum, or a forum specific for the software in question.
As general advice I would suggest you sell your current RAM kit and buy a matched set of 32/64 GB whatever you decide.
Mismatching and mixing RAM kits can cause weird issues with stability. I've seen many people come to forums with intermittent hangs and freezes amongst other strange issues that were solved by changing to a matched RAM kit or a kit on the motherboard QVL.
Its not always a problem but if its a work machine you probably dont want to take that risk.