Weird West sits pretty high on my Steam wishlist, and it looks like an interesting & bizarre RPGish isometric game from the perspectives of 5 different characters. But I've never heard the term "twin-stick shooter" before, so I'm not really sure what it means.
I've played a lot of Isometric RPGs over the years, games with real time combat like Diablo, games with real time w/pause like Pillars of Eternity, and games with turn based combat like Divinity Original Sin. From the videos on the Steam page, WW appears to have real time combat, but I don't know what that "twin stick" term refers to. Sounds like something you'd do with a controller.